PKR-IN-C16
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PKR-IN-C16

SKU T16550-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 58 CAD through 1,075 CAD

Products Details

Product Description

– PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

Web ID

– T16550

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C13H8N4OS

References

– Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.

CAS Number

– 608512-97-6

Molecular Weight

– C13H8N4OS

Compound Purity

– 0.978

SMILES

– O=C1Nc2ccc3ncsc3c2C1=Cc1cnc[nH]1

Target

– Others

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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