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PF-5190457
$90 – $1,250
Products Details
Product Description
– PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36[1].
Web ID
– HY-12584
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C29H32N6OS
References
– [1]Bhattacharya SK, et al. Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate. ACS Med Chem Lett. 2014 Feb 24;5(5):474-9.
CAS Number
– 1334782-79-4
Molecular Weight
– 512.67
Compound Purity
– 98.34
SMILES
– CC1=NC=NC(C2=CC(CC[C@H]3N4CC5(CCN(C(CC6=CN7C=C(C)SC7=N6)=O)CC5)C4)=C3C=C2)=C1
Clinical Information
– Phase 2
Research Area
– Metabolic Disease; Endocrinology
Solubility
– DMSO : 250 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
Target
– GHSR
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
