PCSK9-IN-10
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PCSK9-IN-10

SKU T72025-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 56 CAD through 986 CAD

Products Details

Product Description

– PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Lipoprotein Receptor (LDLR) protein and reducing PCSK9 expression, PCSK9-IN-10 effectively decreases atherosclerosis progression. This compound holds promise for hyperlipidemia research applications.

Web ID

– T72025

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H23N5O4

References

– Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2023;247:115047.

CAS Number

– 368434-98-4

Molecular Weight

– C18H23N5O4

Compound Purity

– 0.9885

SMILES

– COCCNc1nc2n(C)c(=O)n(C)c(=O)c2n1Cc1cccc(OC)c1

Pathway

– Cell Cycle/Checkpoint|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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