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Products Details
Product Description
– PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM.
Web ID
– HY-134482
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C65H80FN11O12S2
References
– [1]Alleyne C, et al. Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J Med Chem. 2020 Nov 25;63(22):13796-13824.
CAS Number
– 2730022-10-1
Molecular Weight
– 1290.53
SMILES
– O[C@H](C)[C@@H](C(N[C@@H](CC1=CC=C(OC)C=C1)C(N2[C@@](C(NCCSC3)=O)(C)CCC2)=O)=O)NC([C@H]4NC([C@H](CC5=CNC6=C5C=C(F)C=C6)NC([C@H](CC7=CC(CNC(CC4)=O)=CC=C7)NC([C@@H](C)NC([C@H](C)NC(CCSCC8=CC=CC3=C8)=O)=O)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
