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Products Details
Product Description
– PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor[1].
Web ID
– HY-149398
Shipping
– Room temperature
Molecular Formula
– C25H23IN8O3
References
– [1]Zhang L, et al. Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer. Eur J Med Chem. 2023 Jul 16;259:115648.
Molecular Weight
– 610.41
SMILES
– NC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CDK;PARP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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