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Products Details
Product Description
– P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
Web ID
– HY-148558
Shipping
– Room temperature
Molecular Formula
– C17H12ClF3N6O
References
– [1]Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6.
CAS Number
– 1627900-92-8
Molecular Weight
– 408.76
SMILES
– O=C(N1CC2=C(CC1)N(C3=NC=CC=N3)N=N2)C4=CC=CC(C(F)(F)F)=C4Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– P2X Receptor
Isoform
– P2X7 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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