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Product Description
– Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2[1][2]. Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity[3][4].
Web ID
– HY-10969A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H19N3O
Citations
– ACS Infect Dis. 2023 Oct 5.|Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.|Departamento de BiotecnologÃa – Departament de Biotecnologia. 2020 Sep 7. |Am J Cancer Res. 2019 Mar 1;9(3):546-561.|Biomed Pharmacother. 2020 Sep;129:110371.|Cancer Lett. 2022 Nov 30;216028.|iScience. 13 August 2022, 104925.|Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct.|Sci Rep. 2019 Sep 24;9(1):13786.|Viruses. 2020 Oct 18;12(10):1178.
References
– [1]Or CR, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1).|[2]Sulkshane P, et al. BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Oncotarget. 2016 Aug 5;8(36):60060-60079.|[3]Ehrenkaufer G, et al. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 Mar 20;14(3):e0008150.|[4]Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26.
CAS Number
– 803712-67-6
Molecular Weight
– 317.38
Compound Purity
– 99.0
SMILES
– COC1=CC(C(N2)=CC3=C2C=CC=C3)=N/C1=CC4=C(C)C=C(C)N4
Clinical Information
– Phase 3
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Autophagy;Bcl-2 Family;Parasite
Isoform
– Bcl-2;Bcl-B;Bcl-W;Bcl-xL;Mcl-1
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
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