Nutlin-3a
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Nutlin-3a

SKU T6023-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 72 CAD through 989 CAD

Products Details

Product Description

– Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.

Web ID

– T6023

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C30H30Cl2N4O4

References

– Tovar C, et al. Proc Natl Acad Sci U S A, 2006, 103(6), 1888-1893.

CAS Number

– 675576-98-4

Molecular Weight

– C30H30Cl2N4O4

Compound Purity

– 0.9971

SMILES

– COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

Pathway

– Ubiquitination|||Apoptosis|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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