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Nitrocaramiphen (hydrochloride)
$90 – $450
Products Details
Product Description
– Nitrocaramiphen hydrochloride is a selective M1 receptor antagonist (Ki: 5.5 nM). Nitrocaramiphen Hydrochloride inhibits the hyperpolarizing effect of muscarine in the muscle fibers[1][2][3].
Web ID
– HY-100945
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H27ClN2O4
References
– [1]Hudkins RL, et al. Caramiphen, iodocaramiphen and nitrocaramiphen are potent, competitive, muscarinic M1 receptor-selective agents. Eur J Pharmacol. 1993 Feb 16;231(3):485-8.|[2]Naumenko NV, et al. [Pharmacological parameters of muscarinic cholinoreceptors in skeletal muscles]. Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):619-26.|[3]Hussain RI, et al. Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol. 2009 Feb;156(4):575-86.
CAS Number
– 98636-73-8
Molecular Weight
– 370.87
Compound Purity
– 99.62
SMILES
– O=C(C1(C2=CC=C([N+]([O-])=O)C=C2)CCCC1)OCCN(CC)CC.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic)
Target
– mAChR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
