Nesolicaftor

$130$1,870

Products Details

Product Description

– Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier[1].

Web ID

– HY-111680

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Molecular Formula

– C18H18N4O4

References

– [1]Arianna Venturini, et al. Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene. Int J Mol Sci. 2021 Nov 4;22(21):11972.|[2]Mijnders M, et al. Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis. Curr Opin Pharmacol. 2017 Jun;34:83-90.

CAS Number

– 1953130-87-4

Molecular Weight

– 354.36

Compound Purity

– 99.65

SMILES

– O=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3

Clinical Information

– Phase 2

Research Area

– Endocrinology

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– Autophagy;CFTR

Pathway

– Autophagy;Membrane Transporter/Ion Channel

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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