Necrosulfonamide
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Necrosulfonamide

SKU T6904-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 83 CAD through 1,509 CAD

Products Details

Product Description

– (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

Web ID

– T6904

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C18H15N5O6S2

Citations

– 1. Zhang J, Zhou B, Sun R, et al. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Research. 2021: 1-18. 2. Yang W, Liu S, Li Y, et al. Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia. Cancer Letters. 2020 3. Teng J F, Mei Q B, Zhou X G, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer MLA. Cancers. 2020, 12(1): 193. 4. Shan G, Bi G, Zhao G, et al.Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer.Respiratory Research.2023, 24(1): 1-15. 5. Jiang X, Zhang X, Cai X, et al.NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.Science Advances.2024, 10(6): eadi9284. 6. Liao W, Zhang R, Chen G, et al.Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway.Biomedicine & Pharmacotherapy.2024, 176: 116832. 7. Bian Y, Shan G, Liang J, et al.Retinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma.Communications Biology.2024, 7(1): 1-13. 8. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024 9. Bian Y, Shan G, Bi G, et al.Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis.Redox Biology.2024: 103361. 10. Yang W, Xu Y, Liu S, et al.Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect.Journal of Advanced Research.2025

References

– Daohong Liao, et al. Med Chem Commun. 2014, 5, 333.

CAS Number

– 1360614-48-7

Molecular Weight

– C18H15N5O6S2

Compound Purity

– 0.9949

SMILES

– COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc(s2)[N+]([O-])=O)cc1

Pathway

– MAPK

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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