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Products Details
Product Description
– MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].
Web ID
– HY-146735
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H24N6O
References
– [1]Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.
CAS Number
– 2771087-94-4
Molecular Weight
– 448.52
SMILES
– N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;MNK
Isoform
– MNK1;MNK2
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
