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ML218
Price range: 86 CAD through 867 CAD
Products Details
Product Description
– ML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).
Web ID
– T12076L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H26Cl2N2O
References
– Xiang Z, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742.
CAS Number
– 1346233-68-8
Molecular Weight
– C19H26Cl2N2O
Compound Purity
– 0.9945
SMILES
– [H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
Target
– Others
Pathway
– Membrane transporter/Ion channel|||Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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