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ML-SA1
Price range: 50 CAD through 925 CAD
Products Details
Product Description
– ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].
Web ID
– T23004
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H22N2O3
Citations
– 1. Xia Q, Zheng H, Li Y, et al.SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.Autophagy.2023: 1-17.
2. Xia Q, Liu X, Zhong L, et al.SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.Autophagy.2024 (just-accepted).
References
– Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.
CAS Number
– 332382-54-4
Molecular Weight
– C22H22N2O3
Compound Purity
– 0.9971
SMILES
– CC1CC(C)(C)N(C(=O)CN2C(=O)C3=CC=CC=C3C2=O)C2=C1C=CC=C2
Pathway
– Membrane transporter/Ion channel
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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