ML-SA1

$58$308

Products Details

Product Description

– ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

Web ID

– HY-108462

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C22H22N2O3

References

– [1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

CAS Number

– 332382-54-4

Molecular Weight

– 362.42

Compound Purity

– 99.50

SMILES

– O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O

Clinical Information

– No Development Reported

Research Area

– Infection

Solubility

– DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 65°C)

Target

– Flavivirus;TRP Channel

Pathway

– Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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