MKT-077

SKU T5152-1 mL * 10 mM (in DMSO) Category Dye-Reagents Brand: TargetMol

Price range: 50 CAD through 850 CAD

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Product Description

– MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s: 1.4-2.2 μM in vitro) through its ability to inhibit members of the Hsp70 family of molecular chaperones.

Web ID

– T5152

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H22ClN3OS2

Citations

– 1. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11.

References

– Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603.

CAS Number

– 147366-41-4

Molecular Weight

– C21H22ClN3OS2

Compound Purity

– 0.982

SMILES

– [Cl-].CCn1c(=Cc2cccc[n+]2CC)sc(=C2/Sc3ccccc3N2C)c1=O

Pathway

– Metabolism|||Cytoskeletal Signaling

Product type

– Dye-Reagents

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

MKT-077

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