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Metarrestin
Price range: 54 CAD through 2,592 CAD
Products Details
Product Description
– Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
Web ID
– T12006
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C31H30N4O
Citations
– 1. Cerrato G, Liu P, Zhao L, et al.AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity.Molecular Cancer.2024, 23: 275.
References
– Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080.
CAS Number
– 1443414-10-5
Molecular Weight
– C31H30N4O
Compound Purity
– 0.9904
SMILES
– O[C@H]1CC[C@@H](CC1)n1cnc2n(Cc3ccccc3)c(c(-c3ccccc3)c2c1=N)-c1ccccc1
Target
– ADC Linker
Pathway
– DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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