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LY2109761
Price range: 62 CAD through 1,230 CAD
Products Details
Product Description
– LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
Web ID
– T2123
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H27N5O2
Citations
– 1. Huang X, Han L, Wang R, et al. Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy. Drug Delivery. 2022, 29(1): 1358-1369
2. Lu Z Z, Sun C, Zhang X, et al.Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.Science Advances.2023, 9(21): eadg1778.
3. Han L, Huang X, Zhao B, et al.TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy.Cancer Immunology, Immunotherapy.2023: 1-17.
4. Ouyang S, Shi S, Ding W, et al.Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops.Advanced Science.2407967
References
– Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-40.
CAS Number
– 700874-71-1
Molecular Weight
– C26H27N5O2
Compound Purity
– 0.9964
SMILES
– C(CN1CCOCC1)Oc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1
Pathway
– Stem Cells|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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