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Products Details
Product Description
– LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].
Web ID
– HY-100469
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C32H31F6N3O7
References
– [1]Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.
CAS Number
– 1949801-52-8
Molecular Weight
– 683.59
SMILES
– OC(C(F)(F)F)(C(F)(F)F)C1=CC(CCC)=C(OC2=CC(O)=C(C(CN3C(N[C@@](C)(C4=NC=C(OC(C)C)C=C4)C3=O)=O)=O)C=C2)C=C1
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– LXR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
