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Lurasidone

SKU HY-B0032A-10 mg Category Reference compound Tags 5-HT Receptor;Dopamine Receptor, GPCR/G Protein;Neuronal Signaling, Neurological Disease

$50 – $660

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Products Details

Product Description

– Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

Web ID

– HY-B0032A

Storage Temperature

– 4°C (Powder, protect from light)

Shipping

– Room Temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C28H36N4O2S

Citations

– Marmara Pharm J. 2017;21 (4): 931-937.|Marmara Pharm J. 2017;21 (4): 931-937.|Nature. 2023 Nov 7.|Marmara Pharm J. 2017;21 (4): 931-937.

References

– [1]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.|[2]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.

CAS Number

– 367514-87-2

Molecular Weight

– 492.68

Compound Purity

– 99.90

SMILES

– O=C([C@H]1[C@H]2C[C@H](CC2)[C@@H]31)N(C[C@H](CCCC4)[C@@H]4CN5CCN(CC5)C6=NSC7=CC=CC=C67)C3=O

Clinical Information

– Launched

Research Area

– Neurological Disease

Solubility

– DMSO : 20.83 mg/mL (ultrasonic)|Ethanol : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– 5-HT Receptor;Dopamine Receptor

Isoform

– 5-HT1 Receptor;5-HT7 Receptor;D2 Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.