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Products Details
Product Description
– LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer[1].
Web ID
– HY-155115
Shipping
– Room temperature
Molecular Formula
– C24H25N3
References
– [1]Dai XJ, et al. Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer. Eur J Med Chem. 2023 Nov 5;259:115684.
CAS Number
– 2904571-94-2
Molecular Weight
– 355.48
SMILES
– CC1=CC=C2C(C(NC3=CC=C(N(C)C)C=C3)=C4C(C(C)=C(C)C=C4)=N2)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase;PD-1/PD-L1
Pathway
– Epigenetics;Immunology/Inflammation
Product type
– Reference compound
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