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Loperamide (hydrochloride)
$66 – $99
Products Details
Product Description
– Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist[1][2][3]. Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect[4].
Web ID
– HY-B0418A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H34Cl2N2O2
References
– [1]Hanauer, S.B., The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord, 2008. 8(1): p. 15-20.|[2]Litovitz, T., et al., Surveillance of loperamide ingestions: an analysis of 216 poison center reports. J Toxicol Clin Toxicol, 1997. 35(1): p. 11-9.|[3]http://www.drugs.com/mmx/loperamide-hydrochloride.html|[4]Hatfield MJ, et al. Carboxylesterase inhibitors. Expert Opin Ther Pat. 2011 Aug;21(8):1159-71.|[5]Svenja Zielke, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2021, 17, 9.
CAS Number
– 34552-83-5
Molecular Weight
– 513.49846
Compound Purity
– 99.77
SMILES
– O=C(N(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.Cl
Clinical Information
– Launched
Research Area
– Metabolic Disease; Neurological Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)
Target
– Autophagy;Opioid Receptor
Pathway
– Autophagy;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
