Linsitinib
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Linsitinib

SKU T6017-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 373 CAD

Products Details

Product Description

– OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

Web ID

– T6017

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H23N5O

Citations

– 1. Chen F, Shi Q, Pei F, et al. A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection. Molecular Systems Biology. 2021, 17(8): e10239 2. Kang J, Guo Z, Zhang H, et al. Dual Inhibition of EGFR and IGF-1R Signaling Leads to Enhanced Antitumor Efficacy against Esophageal Squamous Cancer. International Journal of Molecular Sciences. 2022, 23(18): 10382 3. Yang N, Fan Z, Sun S, et al.Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation.European Journal of Medicinal Chemistry.2023: 115857. 4. Guan J, Borenäs M, Xiong J, et al.IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway.Cancers.2023, 15(17): 4252. 5. Alhaddad H, Ospina O E, Khaled M L, et al.Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.Cell Reports Medicine.2024

References

– Mulvihill MJ, et al. Future Med Chem, 2009, 1(6), 1153-1171.

CAS Number

– 867160-71-2

Molecular Weight

– C26H23N5O

Compound Purity

– 0.9992

SMILES

– NC=1C=2N(C(=NC2C3=CC4=C(C=C3)C=CC(=N4)C5=CC=CC=C5)[C@H]6C[C@@](C)(O)C6)C=CN1

Pathway

– Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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