LG100268
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LG100268

SKU T19703-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 59 CAD through 1,360 CAD

Products Details

Product Description

– LG100268 is a potent, selective, and orally active retinoid X receptor (RXR) agonist that agonizes RXR-α, RXR-β, and RXR-γ at the nanomolar level, selectively exceeding the RAR by three orders of magnitude.LG100268 is capable of inducing transcriptional activation in adipocytes; affecting the RXRs and their chaperone receptor, Foxl2/Dmrt1, to induce flounder masculinization in juvenile flounder; inhibits keratin 17 expression in nigrostriatal epithelial cells; and increases PD-L1 expression in HER2 or triple-negative breast cancer.

Web ID

– T19703

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H29NO2

References

– Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT. The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice. Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. PubMed PMID: 26554632.

CAS Number

– 153559-76-3

Molecular Weight

– C24H29NO2

Compound Purity

– 0.9983

SMILES

– O=C(O)C1=CN=C(C=C1)C2(C=3C=C4C(=CC3C)C(C)(C)CCC4(C)C)CC2

Target

– Others

Pathway

– Cell Cycle/Checkpoint|||Apoptosis|||Metabolism|||Immunology/Inflammation

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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