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Products Details
Product Description
– LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator[1].
Web ID
– HY-148527
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C39H43ClN4O9S2
References
– [1]Aparici M, et al. Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule. Pulm Pharmacol Ther. 2017 Oct;46:1-10.
CAS Number
– 1347232-69-2
Molecular Weight
– 811.36
SMILES
– COC(C=C(NC(OCCN(C)[C@@H]1CC[C@@H](OC(C(O)(C2=CC=CS2)C3=CC=CS3)=O)CC1)=O)C(Cl)=C4)=C4CNC[C@H](O)C5=CC=C(O)C(N6)=C5C=CC6=O
Clinical Information
– Phase 1
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;mAChR
Isoform
– mAChR1;mAChR2;mAChR3;mAChR4;mAChR5;β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
