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Products Details
Product Description
– L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].
Web ID
– HY-100781A
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C4H10NO5P
References
– [1]Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989.|[2]Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6.
CAS Number
– 23052-81-5
Molecular Weight
– 183.10
Compound Purity
– 99.0
SMILES
– O=C(O)[C@@H](N)CCP(O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– H2O : 50 mg/mL (ultrasonic)
Target
– mGluR
Isoform
– mGluR4;mGluR6;mGluR7;mGluR8
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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