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Products Details
Product Description
– KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1].
Web ID
– HY-156422
Shipping
– Room temperature
Molecular Formula
– C26H21N5O3S2
References
– [1]Yukihiro Itoh, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. J Med Chem. 2023 Oct 17. doi: 10.1021/acs.jmedchem.3c01095. Online ahead of print.
CAS Number
– 2397562-43-3
Molecular Weight
– 515.61
SMILES
– NC1=C(C=C(C=C1)C2=CC=CS2)NC(C3=CC=C(C=C3)C4=CN(N=N4)CS(C5=CC=CC=C5)(=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– HDAC
Isoform
– HDAC1;HDAC2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
