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KDM5-C70
$175 – $1,295
Products Details
Product Description
– KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].
Web ID
– HY-120400
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H28N4O3
References
– [1]Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.|[2]Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3’UTR length. Sci Adv. 2016 Nov 18;2(11):e1501662.
CAS Number
– 1596348-32-1
Molecular Weight
– 336.43
Compound Purity
– 97.08
SMILES
– O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Histone Demethylase
Isoform
– KDM5
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
