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KAG-308
Price range: 21,600 CAD through 42,720 CAD
Products Details
Product Description
– KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-α production.
Web ID
– T15642
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H30F2N4O3
References
– Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89.
CAS Number
– 1215192-68-9
Molecular Weight
– C24H30F2N4O3
SMILES
– [H][C@]12C[C@@H](O)[C@H](C=C[C@@H](O)[C@H](C)c3cccc(C)c3)[C@@]1([H])C(F)(F)C(O2)=CCCCc1nnn[nH]1
Target
– Others
Pathway
– GPCR/G Protein|||Immunology/Inflammation
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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