JNJ-63576253 free base
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JNJ-63576253 free base

SKU T8933-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 909 CAD

Products Details

Product Description

– JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).

Web ID

– T8933

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C23H21F3N6O2S

References

– Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 28;64(2):909-924.

CAS Number

– 2110426-27-0

Molecular Weight

– C23H21F3N6O2S

Compound Purity

– 0.9832

SMILES

– FC(F)(F)c1cc(cnc1C#N)N1C(=S)N(c2ccc(OC3CCNCC3)nc2)C2(CCC2)C1=O

Pathway

– Endocrinology/Hormones

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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