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JB061
Price range: 53 CAD through 1,579 CAD
Products Details
Product Description
– JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 μM. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 μM.
Web ID
– T67951
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H17NO4
References
– Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2023;247:115008.
Molecular Weight
– C19H17NO4
Compound Purity
– 0.9876
SMILES
– COc1cccc(CN=C(/C)c2c(O)c3ccccc3oc2=O)c1
Pathway
– Cytoskeletal Signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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