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Products Details
Product Description
– HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity[1].
Web ID
– HY-147841
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C16H15F2N3OS
References
– [1]Ling X, et al. Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase. Eur J Med Chem. 2022 Aug 5;238:114512.
Molecular Weight
– 335.37
SMILES
– CC1=C(N=C(NC1=O)SC(C)C)C(C2=C(C=CC=C2F)F)C#N
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
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