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Hematoporphyrin (dihydrochloride)
$72
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Products Details
Product Description
– Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3].
Web ID
– HY-B0754A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Molecular Formula
– C34H40Cl2N4O6
Citations
– ACS Nano. 2023 Nov 21.|Free Radic Biol Med. 2023 Jul 25;207:239-246.|Pharmaceutics. 2023 Aug 3, 15(8), 2076.|Chem Eng J. 390 (2020) 124521.|Drug Deliv. 2022 Dec;29(1):3358-3369.|FEBS Lett. 2021 Jan;595(2):206-219.|Int J Mol Sci. 2022 Apr 11;23(8):4218.|J Biol Chem. 2022 Aug 26;102417.|Lasers Med Sci. 2020 Feb;35(1):71-78.|Nat Biomed Eng. 2022 Dec 22.|Nat Commun. 2022 Jun 16;13(1):3468.|PLoS One. 2019 Sep 25;14(9):e0222331.
References
– [1]Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.|[2]Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53.|[3]Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
CAS Number
– 17696-69-4
Molecular Weight
– 671.61
Compound Purity
– 98.0
SMILES
– O=C(O)CCC1=C2/C=C3C(CCC(O)=O)=C(C)C(/C=C(N/4)/C(C)=C(C(O)C)C4=CC5=N/C(C(C(O)C)=C5C)=CC(N2)=C1C)=N/3.Cl[H].Cl[H]
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;Endogenous Metabolite
Isoform
– Human Endogenous Metabolite
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
