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Products Details
Product Description
– HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM[1].
Web ID
– HY-143241
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H26N6O3
References
– [1]Lu D, et al. Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy. Bioorg Chem. 2022 Mar;120:105604.
CAS Number
– 2857097-33-5
Molecular Weight
– 446.50
SMILES
– COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;MDM-2/p53
Isoform
– HDAC1;HDAC6
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
