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Products Details
Product Description
– HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM[1].
Web ID
– HY-143241
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H26N6O3
References
– [1]Lu D, et al. Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy. Bioorg Chem. 2022 Mar;120:105604.
CAS Number
– 2857097-33-5
Molecular Weight
– 446.50
SMILES
– COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HDAC;MDM-2/p53
Isoform
– HDAC1;HDAC6
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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