Download Files:
Products Details
Product Description
– These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic50 = 194 nm; Hsp90 α Ic50 = 153 nm) and compound 26 ((HDAC ic50= 360 nm; Hsp90 α Ic50 = 77 nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.
Web ID
– HY-146212
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– N/A
References
– [1]Mehndiratta S,et al. N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression. Eur J Med Chem. 2020 Jan 1;185:111725.
Molecular Weight
– N/A
SMILES
– CC(C1=CC(C(N(C2=CC=C(C=C2)NC(CC(NO)=O)=O)C)=O)=C(C=C1O)O)C.[n].[n=6,7]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;HSP
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
