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Products Details
Product Description
– Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Web ID
– HY-144812
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H22N4O3
References
– [1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.
CAS Number
– 1043922-53-7
Molecular Weight
– 366.41
SMILES
– CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin K
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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