Download Files:
Products Details
Product Description
– Gü1303 is a potent, reversible, slow-binding cathepsin K (CatK) inhibitor with a Ki of 0.91 nM for mature CatK (mCatK). Gü1303 suppresses the autocatalytic activation of the cathepsin K zymogen[1].
Web ID
– HY-144812
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H22N4O3
References
– [1]Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.
CAS Number
– 1043922-53-7
Molecular Weight
– 366.41
SMILES
– CN(N(C([C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)C)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cathepsin
Isoform
– Cathepsin K
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
