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Products Details
Product Description
– GNF-6 (Compound 14), an ATP competitive inhibitor, inhibits the gatekeeper threonine residue mutation of BCR-ABL-T315I with IC50 values of 0.25 μM for c-ABL-T334I, 0.09 μM for BCR-ABL, and 0.590 μM for BCR-ABL-T315I variants. It disrupts the assembly of the hydrophobic spine (a network of hydrophobic interactions), locking the kinase in an inactive ‘DFG-out’ conformation [1].
Web ID
– T86517
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H19F3N6O2
CAS Number
– 839708-29-1
Molecular Weight
– C22H19F3N6O2
SMILES
– O=C1N(CC=2C(N1C)=NC(N)=NC2)C3=CC(NC(=O)C4=CC(C(F)(F)F)=CC=C4)=CC=C3C
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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