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Products Details
Product Description
– GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
Web ID
– HY-101783
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H24N8O
References
– [1]Wang X, et al. Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem. 2017 May 25;60(10):4458-4473.
CAS Number
– 1527523-39-2
Molecular Weight
– 416.48
SMILES
– CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=N4)C=N2)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Pim
Isoform
– PIM1;PIM2;PIM3
Pathway
– JAK/STAT Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
