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GNE-495
$80 – $750
Products Details
Product Description
– GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
Web ID
– HY-100343
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H20FN5O2
References
– [1]Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6(8):913-8.
CAS Number
– 1449277-10-4
Molecular Weight
– 405.42
Compound Purity
– 99.40
SMILES
– O=C(C1=C2C=CC(C3=CC=CC(F)=C3)=NC2=C(N)N=C1)NC4CN(C(C5CC5)=O)C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 2.17 mg/mL (ultrasonic)
Target
– MAP4K
Isoform
– MAP4K4/HGK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
