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GNE-3476
Price range: 3,392 CAD through 5,920 CAD
Products Details
Product Description
– GNE-3476 is an NMDA receptor PAM. Ge-3476 has different degrees of activity on different receptors.GNE-3476 has relatively low efficacy on GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing receptors.
Web ID
– T31979
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H22N4OS
References
– Volgraf, M.; Sellers, B. D.; Jiang, Y.; Wu, G.; Ly, C. Q.; Villemure, E.; Pastor, R. M.; Yuen, P. W.; Lu, A.; Luo, X.; Liu, M.; Zhang, S.; Sun, L.; Fu, Y.; Lupardus, P. J.; Wallweber, H. J.; Liederer, B. M.; Deshmukh, G.; Plise, E.; Tay, S.; Reynen, P.; Herrington, J.; Gustafson, A.; Liu, Y.; Dirksen, A.; Dietz, M. G.; Liu, Y.; Wang, T. M.; Hanson, J. E.; Hackos, D.; Scearce-Levie, K.; Schwarz, J. B. Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): Tuning deactivation kinetics via structure-based design. J. Med. Chem. 2016, 59, 2760−2779.
CAS Number
– 951499-16-4
Molecular Weight
– C18H22N4OS
SMILES
– O=C1N2C(=NC(CN(CC)C3=CC=CC=C3)=C1)SC(CCCC)=N2
Target
– Others
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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