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Products Details
Product Description
– GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM)[1].
Web ID
– HY-148238
Shipping
– Room temperature
Molecular Formula
– C24H27FN6O4
References
– [1]Rajapaksa NS, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett. 2019 Nov 11;11(3):327-333.
CAS Number
– 2102170-43-2
Molecular Weight
– 482.51
SMILES
– O=C(C1=C2N(C=CC=N2)N=C1)NC3=C(N4CCOCC4)C=C5C(CN(C5=O)C[C@@H](F)C(C)(O)C)=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– IRAK
Isoform
– IRAK4
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
