GNE-049

SKU T15397-5 mg Category Small Compound Brand: TargetMol

Price range: 424 CAD through 1,496 CAD

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Product Description

– GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay), and also inhibits BRET and BRD4(1) with IC50 values of 12 nM and 4200 nM, respectively.

Web ID

– T15397

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H32F2N6O2

Citations

– 1. Nguyen D T, Mahajan U, Angappulige D H, et al.Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer.Cancers.2024, 16(9): 1622.

References

– Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.

CAS Number

– 1936421-41-8

Molecular Weight

– C27H32F2N6O2

SMILES

– CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F

Target

– Others

Pathway

– Chromatin/Epigenetic

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

GNE-049

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