Glembatumumab vedotin

$870$2,600

$870
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Products Details

Product Description

– Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects[1].

Web ID

– HY-141604

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– N/A

References

– [1]Christopher H Keir, et al. The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer. Expert Opin Biol Ther. 2012 Feb;12(2):259-63. |[2]Vincent A Pollack, et al. Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB. Cancer Chemother Pharmacol. 2007 Aug;60(3):423-35. |[3]Michael Roth, et al. Targeting Glycoprotein NMB With Antibody-Drug Conjugate, Glembatumumab Vedotin, for the Treatment of Osteosarcoma. Pediatr Blood Cancer. 2016 Jan;63(1):32-8.

CAS Number

– 1182215-65-1

Molecular Weight

– N/A

SMILES

– [Glembatumumab vedotin]

Clinical Information

– Phase 2

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Antibody-Drug Conjugates (ADCs);Microtubule/Tubulin

Pathway

– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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