Fosmanogepix
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Fosmanogepix

SKU T11314-25 mg Category Brand:

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Products Details

Product Description

– Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.

Web ID

– T11314

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H21N4O6P

References

– Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18.

CAS Number

– 2091769-17-2

Molecular Weight

– C22H21N4O6P

SMILES

– O=P([O-])(O)OC[N+]1=CC=CC(C=2ON=C(C2)CC3=CC=C(C=C3)COC4=NC=CC=C4)=C1N

Target

– CGRP Receptor

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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