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Foliglurax (monohydrochloride)
$450 – $3,300
Products Details
Product Description
– Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
Web ID
– HY-108703A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C23H24ClN3O3S
References
– [1]Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537.|[2]Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.
CAS Number
– 2133294-96-7
Molecular Weight
– 457.97
Compound Purity
– 98.93
SMILES
– O/N=C1C=C(C2=CC3=C(C=CS3)C=N2)OC4=CC=C(CCCN5CCOCC5)C=C14.Cl
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– mGluR
Isoform
– mGluR4
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
