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Fluorobexarotene
SKU
HY-108525-10 mg
Category Reference compound
Tags Cancer, Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor, RAR/RXR
$451 – $950
Products Details
Product Description
– Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene[1].
Web ID
– HY-108525
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H27FO2
References
– [1]Wagner CE, et al. Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J Med Chem. 2009 Oct 8;52(19):5950-66.
CAS Number
– 1190848-23-7
Molecular Weight
– 366.47
Compound Purity
– 99.23
SMILES
– O=C(O)C1=CC=C(C(C2=C(C)C=C3C(C)(C)CCC(C)(C)C3=C2)=C)C=C1F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 36 mg/mL (ultrasonic;warming)
Target
– RAR/RXR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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