Products Details

Product Description

– FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].

Web ID

– HY-155529

Shipping

– Room temperature

Molecular Formula

– C21H20F2N4O2S

References

– [1]Xiang R, et al. Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171. Eur J Med Chem. 2023 Sep 5;257:115514.

CAS Number

– 1422456-47-0

Molecular Weight

– 430.47

SMILES

– O=C(C1=CSC(C2=C(F)C=CC=C2F)=N1)NC3=C(O[C@H]4CC[C@H](N)CC4)C=CN=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Pim

Pathway

– JAK/STAT Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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