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Ex26
$344 – $550
Products Details
Product Description
– Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].
Web ID
– HY-117213
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C28H28ClFN2O3
References
– [1]Stuart M Cahalan, et al. Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist. Mol Pharmacol. 2013 Feb;83(2):316-21.
CAS Number
– 1233332-37-0
Molecular Weight
– 494.98
SMILES
– O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– LPL Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
