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Everolimus
Price range: 59 CAD through 501 CAD
Products Details
Product Description
– Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
Web ID
– T1784
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C53H83NO14
Citations
– 1. Nian Z, Zheng X, Dou Y, et al. Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells. Clinical Cancer Research. 2021
2. Sun R, Ge W, Zhu Y, et al.Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.Molecular & Cellular Proteomics.2023: 100602.
3. Dong S, Matossian M D, Yousefi H, et al.Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy.Scientific Reports.2023, 13(1): 11843.
4. Hong J H, Yong C H, Heng H L, et al.Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies.Gut.2023
5. Sun Y, Wu J, Shen B, et al.Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation.International Journal of Molecular Sciences.2025, 26(3): 1381.
References
– Zhu Y, et al. Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo. Tumour Biol. 2012 Oct;33(5):1349-62.
CAS Number
– 159351-69-6
Molecular Weight
– C53H83NO14
Compound Purity
– 0.9978
SMILES
– [H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=CC=C(C)[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OCCO)[C@@H](C1)OC
Target
– Antibacterial
Pathway
– Autophagy|||Apoptosis|||PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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