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Products Details
Product Description
– ERα degrader 6 (Compound 31q) is an ERα degrader (KI: 75 nM). ERα degrader 6 also inhibits ARO with an IC50 of 37.7 nM. ERα degrader 6 inhibits tumor growth in MCF-7 tumor xenograft model. ERα degrader 6 can be used for breast cancer research[1].
Web ID
– HY-149081
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H23F3N4O4S
References
– [1]Xin L, et al. Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur J Med Chem. 2023 May 5;253:115328.
Molecular Weight
– 568.57
SMILES
– O=S([C@H]1[C@](O2)([H])C(C3=CC=C(N4N=CN=C4)C=C3)=C(C5=CC=C(O)C=C5)[C@]2([H])C1)(N(C6=CC=CC=C6)CC(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Cytochrome P450;Estrogen Receptor/ERR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
