Endoxifen
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Endoxifen

SKU T4281-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 776 CAD

Products Details

Product Description

– (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.

Web ID

– T4281

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C25H27NO2

Citations

– 1. Wang K, Chen Y, Gao S, et al. Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling[J].. Acta Pharmaceutica Sinica B. 2021, 11(2): 442-455 2. Wang K, Chen Y, Gao S, et al Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling. Acta Pharmaceutica Sinica B. 2020

References

– Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236.

CAS Number

– 110025-28-0

Molecular Weight

– C25H27NO2

Compound Purity

– 0.9966

SMILES

– CCC(=C(c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1

Pathway

– Microbiology/Virology|||Endocrinology/Hormones|||Metabolism

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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